Wash the skin twice daily or as directed by your physician. Rinse thoroughly with warm water. Every day after cleansing and toning, pat a small amount along the brow bone and under the eyes. Apply liberally to skin about 30 minutes prior to sun exposure. Reapply after excessive swimming or sweating. Apply a small amount of serum to uneven skin tone. Use as a spot treatment, not on the entire face. Avoid the delicate eye area.